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Extensive involvement of GM, and particularly of the thalamus, is associated with a wide range of clinical manifestations including cognitive decline, motor deficits, fatigue, painful syndromes, and ocular motility disturbances in patients with MS. In this review, we characterize the neuropathologic, neuroimaging, and clinical features of thalamic involvement in MS. Further, we underscore the contention that neuropathologic and neuroimaging correlative investigations of thalamic derangements in MS may elucidate not heretofore considered pathobiological underpinnings germane to understanding the ontogeny, magnitude, and progression of the disease process. |
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deep gray nuclei
gray matter
iron,brain
MRI
MRI,abnormal
MRI,field strength,high
MRS
multiple sclerosis
neuropathology
thalamus
thalamus,atrophy of
thalamus,lesion of
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